Unique short US2 glycoprotein

UniProtKB accession:  P09713

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Participates in the inhibition of the host immune response. Early protein that redirects newly synthesized major histocompatibility complex (MHC) class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction (PubMed:19121997). In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM.