Histone-arginine methyltransferase CARM1

UniProtKB accession:  Q9WVG6

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:10381882, PubMed:21138967, PubMed:11341840, PubMed:11997499, PubMed:19897492, PubMed:14966289, PubMed:17218272). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling (PubMed:10381882, PubMed:11747826, PubMed:12498683, PubMed:11751582, PubMed:11341840, PubMed:11997499, PubMed:15339660, PubMed:15616592). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (PubMed:11997499, PubMed:16322096, PubMed:17882261, PubMed:19843527). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (PubMed:11713257). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (PubMed:11983685). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (PubMed:18188184). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (PubMed:21138967). Also seems to be involved in p53/TP53 transcriptional activation (PubMed:15186775). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:11701890). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (PubMed:11850402, PubMed:12756295, PubMed:12237300). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (PubMed:30366907). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (By similarity).