Protein Loquacious

UniProtKB accession:  Q9VJY9

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Double-stranded RNA-binding protein which can function in gene silencing by acting with Dcr-1 to enhance its ATP-independent processing of a specific subset of precursor micro-RNAs (pre-miRNAs) to mature miRNAs (PubMed:19635780, PubMed:27184838, PubMed:26769856). Some reports found it was able to enhance the efficiency of pre-miRNA processing by Dcr-1, and can shift the cleavage site of Dcr-1 altering the length of the mature miRNAs produced by Dcr-1 alone (PubMed:17320391, PubMed:23063653, PubMed:29373753). However, in contrast to isoform PB, it is not necessary or sufficient for enhancing miRNA biogenesis, and is not required for development or female germline stem cell (GSC) maintenance (PubMed:17320391, PubMed:23063653). Another report also found that it decreases binding of Dcr-1 to the miRNA substrate let-7 (PubMed:17928574).