Potassium channel toxin alpha-KTx 8.2

UniProtKB accession:  Q9U8D2

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UniProtKB description:  This toxin inhibits rKv1.1/KCNA1 (100% inhibition at 3 uM), Kv1.3/KCNA3 (human, mouse and rat) (IC(50)=269-467 nM), shaker IR (60% at 3 uM) and activates the mouse capsaicin receptor TRPV1 (EC(50)=132 uM, at 20 degrees Celsius), a non-selective cation channel expressed by sensory neurons of the pain pathway (PubMed:26389953, PubMed:20889474). In vivo, intraplantar injection of this toxin in WT mice hind paw shows significant acute pain, whereas no pain is observed when the toxin is injected into TRPV1 KO mice (PubMed:26389953). In addition, subcutaneous injection into mice (185 mg) produces an excitation of the animal, but no lethality, whereas injection into cockroaches does not provoke lethality as well (PubMed:9151979).