Protein numb homolog

UniProtKB accession:  Q9QZS3

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:15273690, PubMed:12410312). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:15273690, PubMed:12410312). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898).