KH domain-containing RNA-binding protein QKI

UniProtKB accession:  Q9QYS9

Grouped By:  Matching UniProtKB accession

UniProtKB description:  RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295, PubMed:36088389). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:10535969, PubMed:11297509, PubMed:11917126, PubMed:12467586, PubMed:15568022, PubMed:31868295). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:16041388). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:37272356). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:37272356). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:10864952, PubMed:12467586, PubMed:11917126, PubMed:15568022, PubMed:20956316, PubMed:21253564). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (PubMed:10864952, PubMed:15568022, PubMed:28188285). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (PubMed:12467586). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (PubMed:11917126, PubMed:20956316, PubMed:21253564). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (PubMed:33378678, PubMed:33045062). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:36088389). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (PubMed:33397958, PubMed:36627242). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (PubMed:31868295). Also required for visceral endoderm function and blood vessel development (PubMed:11892011, PubMed:16470614). May also play a role in smooth muscle development (PubMed:14706070). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (PubMed:33942715, PubMed:34021134).