Feruloyl CoA ortho-hydroxylase 1

UniProtKB accession:  Q9LHN8

Grouped By:  Matching UniProtKB accession

UniProtKB description:  2-oxoglutarate (OG)- and Fe(II)-dependent dioxygenase (2OGD) involved in scopoletin biosynthesis (PubMed:18547395, PubMed:29581584). Converts feruloyl CoA into 6'-hydroxyferuloyl CoA but has no activity with ferulic acid, feruloylquinic acid, caffeic acid, caffeoyl CoA, p-coumaric acid, cinnamic acid, cinnamoyl CoA or benzoyl CoA (PubMed:18547395). Required for the production and secretion of compounds (e.g. fluorescent coumarins) that facilitate the mobilization and uptake of iron from sources with low bioavailability or in high pH-induced iron deficiency conditions (PubMed:23735511, PubMed:24246380). Involved in the pathway of sideretin biosynthesis from feruloyl CoA, a redox-active catecholic metabolite exuded by roots in response to iron deficiency in order to facilitate the uptake of iron; this pathway consists in the successive conversion from feruloyl CoA to scopoletin, from scopoletin to fraxetin and from fraxetin to sideretin (PubMed:29581584). Catalyzes the biosynthesis of scopoletin from feruloyl CoA (PubMed:29581584).