Calcium/calmodulin-dependent protein kinase II inhibitor 1

UniProtKB accession:  Q9JI15

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Potent and specific inhibitor of CaM-kinase II (CAMK2) (PubMed:11182241). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (PubMed:31327268). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268).