Replicase polyprotein

UniProtKB accession:  Q9IJX4

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells (PubMed:20400949). Inhibits siRNA function through the direct enzymatic inactivation of host AGO2, but does not interfere with miRNA pathway (PubMed:20400949). Facilitates viral replication via the recruitment of a cellular ubiquitin ligase complex that promotes host AGO2 degradation (PubMed:30308158). Inhibits the integrated stress response (ISR) in the infected cell possiby by degrading host Nup358 (PubMed:28003491, PubMed:36455064). Stress granule formation is thus inhibited, which allows protein synthesis and viral replication (PubMed:28003491, PubMed:36455064). Does not bind to dsRNA or siRNA (PubMed:20400949).