Cyclic di-GMP phosphodiesterase RocR

UniProtKB accession:  Q9HX69

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UniProtKB description:  Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to 5'-pGpG (PubMed:18344366, PubMed:19376848). Cannot use cyclic AMP or cyclic GMP (PubMed:18344366). Part of the RocSAR two-component regulatory signaling system (also known as the SadARS system), which regulates biofilm maturation, type III secretion and expression of the cup fimbrial-gene cluster (PubMed:15687209, PubMed:15659157). Negatively regulates the expression of cup genes by antagonizing the activity of RocA1 (PubMed:15659157).