Probable serine/threonine-protein kinase zyg-1

UniProtKB accession:  Q9GT24

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions (PubMed:11371350, PubMed:15232593, PubMed:15665853, PubMed:19081077, PubMed:18765790, PubMed:19109417, PubMed:22623721, PubMed:27689799). Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization (PubMed:11371350, PubMed:18765790). Maternal copy regulates centrosome duplication during later cell cycles (PubMed:11371350, PubMed:18765790). Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome (PubMed:15232593, PubMed:15665853). Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, which in turn recruits the spindle checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores (PubMed:18765790, PubMed:18936247).