Lysine-specific demethylase 9

UniProtKB accession:  Q9GRZ3

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UniProtKB description:  Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture (PubMed:28867287). Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression (PubMed:28867287). Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development (PubMed:14660541, PubMed:23028348, PubMed:3779843, PubMed:3478715, PubMed:26641248, PubMed:22393255, PubMed:28867287). X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC) (PubMed:14660541, PubMed:28867287). Required for the enrichment of H4K20me1 on autosomes in meiotic germ cells leading to their compaction in a DCC-independent mechanism (PubMed:28867287). Involved in 3-dimensional chromosome organization by strengthening the borders of topologically associating domains (PubMed:28867287). Involved in the regulation of growth, fecundity and body fat metabolism downstream of the TOR complex 2 and the protein kinase sgk-1 pathway (PubMed:23884442). Also involved in male tail development (PubMed:6537930).