Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

UniProtKB accession:  Q99640

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UniProtKB description:  Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:9268380, PubMed:9001210, PubMed:10504341, PubMed:10373560). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9268380, PubMed:9001210). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9268380, PubMed:9001210).