Hookworm platelet inhibitor 1

UniProtKB accession:  Q962V9

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Hookworms inhibitor of platelet aggregation and adhesion (PubMed:10191228). Native protein inhibits platelet aggregation induced by ADP, epinephrine, and thrombin (PubMed:10191228). In addition, it prevents adhesion of resting platelets to immobilized fibrinogen and collagen (PubMed:10191228). May act by binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) and integrin alpha-2/beta-1 (ITGA1/ITGB1), respectively (PubMed:10191228). It is noteworthy that the recombinant protein fails to inhibit binding to fibrinogen (through ITGA2B/ITGB3) and collagen (through ITGA1/ITGB1) (PubMed:10191228, PubMed:26057788).