Acetyl-coenzyme A synthetase

UniProtKB accession:  Q8ZKF6

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UniProtKB description:  Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine (PubMed:16272400).