Iron-regulated surface determinant protein B

UniProtKB accession:  Q8NX66

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Cell wall-anchored surface receptor that extracts heme from oxidized methemoglobin/metHb to enable growth on hemoglobin as a sole iron source (PubMed:24871270). Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils (PubMed:18097052).