(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase

UniProtKB accession:  Q8GMG6

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UniProtKB description:  Oxygenase component of a two-component system involved in the biosynthesis of the enediyne antitumor antibiotic C-1027 (PubMed:18426211). Uses FADH(2) supplied by SgcE6 to catalyze the C-5 hydroxylation of (S)-3-chloro-beta-tyrosyl-S-SgcC2 (PubMed:18426211). Can also efficiently catalyze the regioselective hydroxylation of other 3-substituted beta-tyrosyl-S-SgcC2 analogs, including the bromo-, iodo-, fluoro-, and methyl-substituted analogs, but does not accept 3-hydroxy-beta-tyrosyl-S-SgcC2 as a substrate (PubMed:18426211). Is only active with SgcC2 (peptidyl carrier protein)-tethered substrates (PubMed:18426211).