Potassium channel toxin alpha-KTx 15.8

UniProtKB accession:  Q86BX0

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UniProtKB description:  Blocker of A-type voltage-gated potassium channels of cerebellar granular cells. May also inhibit Kv4/KCND when coexpressed with DPP6 or DPP10. The occlusion of the outer entry of the K(+) conducting pore is partially reversible and affects both open and closed channels. It shares the same target in rat brain than BmTX3 (AC Q8I0L5) and AmmTX3 (AC P60208). Also shows a weak inhibition on Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels (PubMed:29483648).