Chromo domain-containing protein rhino

UniProtKB accession:  Q7JXA8

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Involved in piRNA (piwi-interacting RNA)-mediated transposon repression (PubMed:19732946, PubMed:36193674). May be involved in formation of the perinuclear nuage, a subcellular structure implicated in RNA processing that may be involved in transposon RNA surveillance and silencing (PubMed:19732946, PubMed:36193674). Required for ping-pong amplification during piRNA biogenesis, probably by promoting transcription of piRNA precursors (PubMed:19732946, PubMed:36193674, PubMed:25085419). As part of the Rhino-Deadlock-Cutoff (RDC) Complex associates with, and drives non-canonical transcription of germline specific dual-strand piRNA clusters 80F, 38C and 42AB, but not single-stranded piRNA cluster 20A (PubMed:19732946, PubMed:36193674, PubMed:24906153, PubMed:25085419). Induction of piRNA expression is potentially achieved through a mechanism that prevents transcriptional termination and leads to readthrough from flanking transcription units (PubMed:24906153). Recruited to specific chromatin regions by a combination of H3K9me2/3 histone methylation and differentially expressed sequence-specific recruitment factors (PubMed:36193674, PubMed:24906153, PubMed:25085419, PubMed:25613572). This association may involve direct interaction with DNA (PubMed:25613572). In ovaries, recruitment to specific heterochromatin clusters is nucleated and stabilized by kipf/kipferl (PubMed:36193674). During oogenesis, involved in axis specification and may regulate chromosome condensation at the onset of a mitotic-like phase that occurs during nurse cell chromosome duplication (PubMed:11729157). Involved in the distribution of mRNAs for proteins that play a role in anterior-posterior and dorsal-ventral axes specification during development of the oocyte, including grk/gurken, osk/oskar and vas/vasa (PubMed:11729157, PubMed:19732946). Mitigates meiotic double strand breaks and interacts with DNA damage signaling to mediate axis specification (PubMed:19732946).