Splicing regulator SDE2
UniProtKB accession: Q6IQ49
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Go to UniProtKB: Q6IQ49
UniProtKB description: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959).
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