Response regulator aspartate phosphatase H

UniProtKB accession:  Q59HN8

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UniProtKB description:  Dual specificity regulatory protein that can control both sporulation and competence by acting on two distinct response regulators: Spo0F and ComA, respectively (PubMed:17581123, PubMed:21346797). Is involved in the temporal separation of competence and sporulation (PubMed:17581123). Acts as a phosphatase that specifically dephosphorylates the sporulation initiation phosphotransferase Spo0F and inhibits its activity (PubMed:17581123, PubMed:21346797). RapH can also antagonize sporulation by sterically blocking phosphoryl transfer to and from Spo0F (PubMed:21346797). In addition, inhibits the activity of ComA, a transcriptional factor that regulates the development of genetic competence (PubMed:17581123). Acts by binding to ComA, leading to the inhibition of its DNA-binding activity (PubMed:17581123).