Antitoxin DinJ

UniProtKB accession:  Q47150

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UniProtKB description:  Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:17263853). A labile antitoxin that counteracts the effect of cognate toxin YafQ (PubMed:17263853). YafQ and DinJ together bind their own promoter, and repress its expression (PubMed:24898247). There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription; binding to a single IR is sufficient for activity in vivo and in vitro (PubMed:24898247). DinJ alone is as potent a transcriptional repressor as the heterotetramer and also only needs to bind 1 IR to act (PubMed:24898247).