Hexokinase-1

UniProtKB accession:  Q42525

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Fructose and glucose phosphorylating enzyme (PubMed:7610198). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (PubMed:16920781). Acts as a sugar sensor which may regulate sugar-dependent gene repression or activation (PubMed:9014361, PubMed:12690200, PubMed:26528314). Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism (PubMed:9014361, PubMed:12690200). May regulate the execution of program cell death in plant cells (PubMed:16920781). Promotes roots and leaves growth (PubMed:26528314). Together with sugar, is involved in the regulation of the expression of aquaporin genes, and reduces leaf water conductance, to coordinate sugar levels with the loss of water through transpiration (PubMed:28390076). Regulates cell proliferation and expansion early during leaf development (PubMed:30511331). Involved in sucrose-induced leaf growth stimulation independently of GPT2 (PubMed:30511331). May participate to the stimulation of hypocotyl elongation under long-day (LD) conditions (PubMed:34155329). Forms a nuclear complex with CLF and EZA1/SWN to target common glucose-responsive genes and regulate glucose signaling (PubMed:35394700). Is required for CLF- and EZA1/SWN-mediated histone H3 trimethylation on 'Lys-27' (H3K27me3) and glucose-mediated gene repression (PubMed:35394700).