5-epi-aristolochene synthase

UniProtKB accession:  Q40577

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UniProtKB description:  Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol (Ref.3, PubMed:16375847). Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene (Ref.3, PubMed:16375847).