Neurexin 1

UniProtKB accession:  Q3KN41

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Neuronal cell adhesion protein involved in synapse formation, development of synaptic active zones, synaptic regulation and visual function (PubMed:17498701, PubMed:17785181, PubMed:19379781, PubMed:20559439, PubMed:22864612, PubMed:23352167, PubMed:26201245, PubMed:26471740). Plays a role in cell adhesion between the pre- and the postsynaptic cell (PubMed:17785181). Required for proper proliferation of synaptic boutons during larval development, a process necessary for coordinated matching of pre-and postsynaptic compartments (PubMed:17785181). Promotes presynaptic active zone formation and neurotransmitter release (PubMed:20559439). Spn/Spinophilin fine-tunes nrx-1/nlg1 signaling at the pre-synapse to control active zone number and functionality and thereby optimizing action potential-induced exocytosis (PubMed:26471740). Required for synapse formation in central nervous system (PubMed:17498701). By regulating synapse formation, may play a role in larval associative learning (PubMed:17498701, PubMed:19379781). Together with RhoGAP100F/syd-1, controls synapse formation at the neuromuscular junction (PubMed:22864612). Essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ) (PubMed:19379781). Regulated and restricts formation of glutamate receptor clusters (PubMed:20559439). Mediates retinoid transport and subsequent rhodopsin maturation and may regulate lipoprotein function; thereby playing a role in vision (PubMed:23352167). Regulates sleep, circadian rhythm and synaptic plasticity (PubMed:26201245). Together with CASK, required for locomotion (PubMed:19379781).