Post-transcriptional regulator MTA

UniProtKB accession:  Q2HR75

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UniProtKB description:  Post-transcriptional regulator that plays an essential role in the expression of viral lytic genes and productive viral replication. Possesses numerous activities that promote the expression of viral genes including enhancement of RNA stability, promotion of RNA splicing and stimulation of protein translation often via its ability to interact with different cellular cofactors. Stabilizes polyadenylated nuclear (PAN) RNA by cooperative binding to a 9-nt core of the MRE (MTA responsive element) together with host PABPC1 (PubMed:23077296). Functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes (PubMed:18184716). Protects viral transcripts from specific nuclear RNA decay pathways by preventing host MTREX recruitment that promotes unwinding and degradation of structured RNA substrates (PubMed:30785952). Plays a role in the inhibition of host P-body formation by altering the scaffolding activity of TNRC6A at the initial stage thereby enhancing virus production (PubMed:31400113). Inhibits also host stress granule formation by blocking autophosphorylation of EIF2AK2/PKR and its subsequent binding to dsRNA (PubMed:29084250).