Calcium uniporter protein, mitochondrial

UniProtKB accession:  Q21121

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UniProtKB description:  Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:25313960, PubMed:31983639). Constitutes a pore-forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding (PubMed:25313960). In addition, together with mitochondrial calcium regulator micu-1, required for mitochondrial calcium uptake following axon injury in PLM touch receptor neurons (PubMed:31983639).