Female germline-specific tumor suppressor gld-1

UniProtKB accession:  Q17339

Grouped By:  Matching UniProtKB accession

UniProtKB description:  RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence (PubMed:24838563). Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA (PubMed:11562350). Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA (PubMed:19758560). Binds sequences in the 3'-UTR region of tra-2 mRNA (PubMed:24838563). Binds to the 3' UTR of Notch receptor homolog glp-1, thereby repressing glp-1 translation in the embryo (PubMed:7601353). Binding to the glp-1 3' UTR is inhibited by pos-1 binding to an overlapping binding site in the glp-1 3' UTR (PubMed:7601353). Germ line-specific tumor suppressor essential for oogenesis (PubMed:7601353). Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline (PubMed:7601353, PubMed:11562350, PubMed:24838563). Represses translation of the vacuolar ATPase component vha-13 in the distal gonad (PubMed:29168500). Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation (PubMed:11562350). By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells (PubMed:19758560, PubMed:21455289).