Cysteine-type anaerobic sulfatase-maturating enzyme

UniProtKB accession:  Q0TTH1

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UniProtKB description:  Involved in 'Cys-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of cysteine ('Cys-51' in the arylsulfatase CPF_0221) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly)), by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM) (PubMed:18408004, PubMed:16766528, PubMed:17335281, PubMed:19489556, PubMed:23477283). Is also able to oxidize a serine residue in a synthetic substrate to FGly in vitro, and in a serine variant of a Cys-type sulfatase in vivo, but this activity is not physiological (PubMed:18408004, PubMed:23477283). Converts threonyl peptides to the corresponding ketone product, and also allo-threonyl peptides, but with a significantly reduced efficiency (PubMed:23477283).