Protein lag-3

UniProtKB accession:  Q09260

Grouped By:  Matching UniProtKB accession

UniProtKB description:  glp-1/Notch and lin-12/Notch proteins promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator, probably as part of a complex with a Notch intracellular domain (NICD) and the transcription regulator lag-1 (PubMed:10830967, PubMed:10884418, PubMed:16530045). Involved in the p53-mediated germ-cell apoptotic response to DNA damage, perhaps acting as a transcriptional activator (PubMed:17317671). May regulate phosphatase lip-1 mRNA transcription downstream of glp-1 (PubMed:16319922).