Iron-regulated transcriptional activator AFT2

UniProtKB accession:  Q08957

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UniProtKB description:  Transcription factor required for iron homeostasis and resistance to oxidative stress (PubMed:11448968, PubMed:11734641, PubMed:12756250, PubMed:15649888, PubMed:16024809). With AFT1, activates the gene expression in response to low-iron conditions, also called iron regulon (PubMed:24591629, PubMed:11448968, PubMed:11734641, PubMed:12756250, PubMed:15649888, PubMed:16024809). Recognizes the consensus iron-responsive element (Fe-RE) sequence 5'-CACCC-3' in the promoters of target genes (PubMed:24591629). The transcription activation by AFT1 and AFT2 depends on the mitochondrial iron-sulfur protein biosynthesis pathway (PubMed:15649888). In high iron condition, the presence of iron leads to dimerization, which in turn leads to a decrease in DNA affinity (PubMed:24591629).