Vacuolar protein sorting-associated protein 38
UniProtKB accession: Q05919
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Go to UniProtKB: Q05919
UniProtKB description: Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:11157979, PubMed:12244127, PubMed:9265642). This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome) (PubMed:11157979, PubMed:12244127, PubMed:9265642). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane (PubMed:11157979).
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