Vacuolar protein sorting-associated protein 30

UniProtKB accession:  Q02948

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I (PubMed:9712845, PubMed:11157979, PubMed:11689437, PubMed:8224160, PubMed:16267277, PubMed:17404498, PubMed:18701704, PubMed:19131141, PubMed:22437838, PubMed:23878393). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (PubMed:9712845, PubMed:11157979, PubMed:11689437, PubMed:8224160, PubMed:16267277, PubMed:17404498, PubMed:18701704, PubMed:19131141, PubMed:22437838, PubMed:23878393). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:11157979, PubMed:12244127, PubMed:9105038, PubMed:18182384). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (PubMed:11157979, PubMed:12244127, PubMed:9105038, PubMed:18182384). Also plays a role in regulation of filamentous growth (PubMed:17700056).