Serine/threonine-protein kinase PknD

UniProtKB accession:  P9WI79

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UniProtKB description:  Part of a signaling pathway that enables adaptation to osmotic stress through cell wall remodeling and virulence factor production (PubMed:24309377). Phosphorylates the osmosensory protein OprA, which inhibits binding of OprA to Rv2638, leading to the regulation of osmotically regulated genes, including the ESX-1-associated virulence factor espA (PubMed:17411339, PubMed:17242402, PubMed:24309377). In addition, directly phosphorylates the alternative sigma factor SigF and its regulator, Rv1364c, which regulates the SigF-Rv1364c interaction (PubMed:30642988). Can also phosphorylate the FHA domain of Rv1747 (PubMed:15987910).