Lactoperoxidase

UniProtKB accession:  P80025

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (PubMed:5338806) (Probable). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (PubMed:354515) (Probable). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:5338806, PubMed:354515). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against some streptococci strains (PubMed:5338806). The lactoperoxidase-I(-)-H2O2 system shows antibacterial properties against E.coli (PubMed:354515). May protect the udder from infection and may promote growth in newborns (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity).