Cytoskeleton bundling-enhancing antitoxin CbeA

UniProtKB accession:  P76364

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Antitoxin component of a type IV toxin-antitoxin (TA) system (PubMed:14594833, PubMed:22515815, PubMed:28257056). Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) (PubMed:14594833, PubMed:22515815, PubMed:28257056). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles (PubMed:22515815). The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833). The intergenic region was not found to be necessary in another study (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape (PubMed:22515815). Also counteracts the effect of non-cognate toxins YfkI and YpjF (PubMed:28257056).