PTS system glucose-specific EIICB component

UniProtKB accession:  P69786

Grouped By:  Matching UniProtKB accession

UniProtKB description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport (PubMed:3129430, PubMed:10562420). Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration and an effector modulating the activity of the transcriptional repressor Mlc (PubMed:18319344). In the presence of glucose in the medium, the dephosphorylated form of PtsG can interact with Mlc, leading to sequestration of Mlc in the inner membrane and inhibition of its repressor activity (PubMed:11032803, PubMed:11157755, PubMed:12529317, PubMed:18319344).