Putative diacylated glycolipid transporter LprF

UniProtKB accession:  P65315

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Might be involved in transporting short diacylated glycolipids to the cell outer membrane. Binds glycolipids that contain a diacylated glycerophosphate or a diacylated phosphatidylinositol moiety with C14 and C16 chains (upon overexpression in M.smegmatis; M.smegmatis does not encode this gene). Overexpression in M.smegmatis increases the cell wall glycolipid LAM/LM ratio (lipoarabinomannan/lipomannan), suggesting perhaps this protein is involved in the preferential translocation of diacylated LAM to the outer cell membrane. Overexpressing M.smegmatis cells adhere less well to hexadecane droplets, indicating decrease in the hydrophobicity of the cell surface, and have a slightly increased resistance to the antibiotic ethambutol.