Glutamate/gamma-aminobutyrate antiporter

UniProtKB accession:  P63235

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Involved in glutaminase-dependent acid resistance (PubMed:8682809, PubMed:30498489). Exchanges extracellular glutamate (Glu) for intracellular gamma-aminobutyric acid (GABA) under acidic conditions (PubMed:22407317, PubMed:23589309). The protonation states of substrates are crucial for transport. Selectively transports Glu with no net charge and GABA with a positive charge (PubMed:23589309). Also efficiently transports glutamine and, to a smaller extent, methionine and leucine (PubMed:22407317). When the extracellular pH drops below 2.5, can import L-glutamine and export either glutamate or GABA (PubMed:30498489). The ability to survive the extremely acidic conditions of the stomach is essential for successful colonization of the host by commensal and pathogenic bacteria (PubMed:8682809, PubMed:30498489).