Mu-conotoxin PIIIA

UniProtKB accession:  P58925

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UniProtKB description:  Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks rNav1.4/SCN4A (IC(50)=36-41 nM) (PubMed:10627583, PubMed:21652775). It also moderately blocks rNav1.1/SCN1A (IC(50)=120 nM), rNav1.2/SCN2A (IC(50)=620 nM), rNav1.3/SCN3A (IC(50)=3.2 uM), mNav1.6/SCN8A (IC(50)=100 nM) (PubMed:10627583, PubMed:21652775). This inhibition is reversible. The block of Nav1.1, Nav1.2, and Nav1.6 is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing the beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing the beta-2 and beta-4 are less potent (compared to channels without beta subunits). In vivo, this peptide causes flaccid paralysis in both mice and fish.