Conjugated bile acid hydrolase

UniProtKB accession:  P54965

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UniProtKB description:  Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in major human bile salts, such as glycocholate (GCA), taurocholate (TCA) and taurodeoxycholate (TDCA) (PubMed:7618863, PubMed:15823032). Shows a slight preference for taurine-conjugated bile acids as substrates (PubMed:7618863).