tRNA(His) guanylyltransferase

UniProtKB accession:  P53215

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Acts as a tRNA(His) guanylyltransferase that catalyzes 3'-5' addition of a single guanosine residue to the -1 position of tRNA(His), to form a non-Watson-Crick G(-1):A-73 base pair (PubMed:14633974, PubMed:16625026, PubMed:18366186, PubMed:24548272, PubMed:33790044). After addition of G(-1), THG1 removes pyrophosphate from the tRNA 5'-end, generating 5'-monophosphorylated G(-1)-containing tRNA which is important for recognition of tRNA(His) by its cognate histidyl-tRNA synthetase (PubMed:24548272). In addition to the single-G(-1) addition reaction, THG1 polymerizes multiple G residues to the 5'-end of tRNA(His) variants using the 3'-end of the tRNA(His) acceptor stem as a template (PubMed:16731615, PubMed:24548272, PubMed:33790044).