DNA-binding transcriptional repressor Mlc

UniProtKB accession:  P50456

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Global regulator of carbohydrate metabolism (PubMed:9484892, PubMed:9484893, PubMed:9781886, PubMed:10464268, PubMed:11361067, PubMed:11934616). Represses the expression of several genes involved in sugar transport and utilization, in particular phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) genes (PubMed:9484892, PubMed:9484893, PubMed:9781886, PubMed:10464268). Represses expression of ptsG (EIICB(Glc)), which encodes the PTS system glucose-specific EIICB component (PubMed:9781886). Also represses the expression of the manXYZ operon, encoding the mannose-specific PTS system, expression of malT, encoding the transcriptional activator of the maltose regulon, and expression of the pts operon, composed of the genes ptsH, ptsI and crr (PubMed:9484892, PubMed:9484893, PubMed:10464268). Represses its own expression (PubMed:9484893). Acts by binding to the regulatory region of the target genes (PubMed:9484893, PubMed:9781886, PubMed:10464268).