Beta-diguetoxin-Dc1a

UniProtKB accession:  P49126

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Insecticidal toxin (PubMed:8541888, PubMed:8896202). This toxin promotes opening of insect Nav channels. The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i.e., receptor site 4). The American cockroach P.americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop. In vivo, paralyzes lepidopteran and dipteran larvae. Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760).