Spindle assembly checkpoint component MAD3

UniProtKB accession:  P47074

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.