4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5
UniProtKB accession: P43534
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Go to UniProtKB: P43534
UniProtKB description: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
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