Carboxypeptidase D

UniProtKB accession:  P42787

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Metallocarboxypeptidase that catalyzes the release of C-terminal arginine or lysine residues from peptides and proteins (PubMed:16556608, PubMed:31309630, PubMed:20600119, PubMed:12393882, PubMed:20386952). Functionally important for processing a broad range of proteins including growth factors, peptide hormones (such as Akh) and neuropeptides (PubMed:16556608, PubMed:27430952, PubMed:31309630, PubMed:20600119, PubMed:20386952). Consequently, it is involved in a wide range of processes including viability, memory formation, locomotive activity, wing formation, and peptide-regulated behaviors such as starvation-induced hyperactivity, appetitive gustatory preference, and cold and ethanol sensitivity (PubMed:27430952, PubMed:31309630, PubMed:20600119, PubMed:20386952). Key enzyme in neuropeptide processing (PubMed:31309630). Involved in regulation of memory formation, possibly via the insulin pathway in neurosecretory cells (PubMed:27430952).