Myosin heavy chain kinase A

UniProtKB accession:  P42527

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UniProtKB description:  Catalyzes its autophosphorylation, which is needed for enzymatic activity and phosphorylates myosin II heavy chain at a threonine in the C-terminal tail region (PubMed:7822274). This phosphorylation is critical for regulating the assembly and disassembly of myosin II filament, affecting myosin localization during an array of cellular contractile events, including cytokinesis and capping of cell surface receptors as well as chemotactic cell locomotion (PubMed:7822274).