Vacuolar protein 8
UniProtKB accession: P39968
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Go to UniProtKB: P39968
UniProtKB description: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole (cvt) (PubMed:9490720). Involved in the formation of nucleus-vacuole junctions (NVJs) during piecemeal microautophagy of the nucleus (PMN) (PubMed:10888680, PubMed:12529432, PubMed:16912077). NVJs are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane (PubMed:10888680, PubMed:12529432, PubMed:16912077). Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process (PubMed:10888680, PubMed:12529432, PubMed:16912077).
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