Plasmepsin I

UniProtKB accession:  P39898

Grouped By:  Matching UniProtKB accession

UniProtKB description:  During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain (PubMed:8313875, PubMed:2007860, PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).